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Antibody agitation may improve cognition


New research suggests the LINGO-1 antibody may be an effective treatment for improving cognitive impairment in multiple sclerosis patients. The findings also suggest that myelin damage may be the cause of the learning and memory impairment.

Researchers led by Jun-Jun Sun of the Department of Neuropsychiatry, at the Southeast University School of Medicine in Nanjing, China, using the mouse model of MS, assessed cognitive function at early and late stages, and investigated whether the LINGO-1 antibody could restore deficits in learning and memory and ameliorate any loss of myelin.

They found that learning and memory impairments occurred in late in disease progression. The LINGO-1 antibody significantly improved learning and memory, partially restored myelin, and activated the signaling pathway that regulates myelin growth.

Results of mouse model studies sometimes do not translate to humans and may be years away from being a marketable treatment. However, the authors note that the research demonstrates that LINGO-1 antagonism may be an effective approach to the treatment of the cognitive impairment of multiple sclerosis patients.

The findings were published in in the journal Science Reports.

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