About Multiple Sclerosis Foundation



Home > Learn About Multiple Sclerosis > News > Antibody agitation may improve cognition

Antibody agitation may improve cognition

9/24/2015

New research suggests the LINGO-1 antibody may be an effective treatment for improving cognitive impairment in multiple sclerosis patients. The findings also suggest that myelin damage may be the cause of the learning and memory impairment.

Researchers led by Jun-Jun Sun of the Department of Neuropsychiatry, at the Southeast University School of Medicine in Nanjing, China, using the mouse model of MS, assessed cognitive function at early and late stages, and investigated whether the LINGO-1 antibody could restore deficits in learning and memory and ameliorate any loss of myelin.

They found that learning and memory impairments occurred in late in disease progression. The LINGO-1 antibody significantly improved learning and memory, partially restored myelin, and activated the signaling pathway that regulates myelin growth.

Results of mouse model studies sometimes do not translate to humans and may be years away from being a marketable treatment. However, the authors note that the research demonstrates that LINGO-1 antagonism may be an effective approach to the treatment of the cognitive impairment of multiple sclerosis patients.

The findings were published in in the journal Science Reports.



  Support the MSF
Supporting MSF's programs to help make "a brighter tomorrow" has never been easier.
make a donation 

  Learn About MS
Common symptoms of MS include fatigue, weakness, spasticity, balance problems, bladder and bowel problems, numbness, vision loss, tremors and depression.
learn more 

 

Unless otherwise specified, all medical content is compiled by MSF staff and reviewed for accuracy by a member of our Medical Advisory Board.

The MSF strives to present clear and unbiased information. This site is partially funded through a grant from Bayer Healthcare, LLC.

© Copyright 2000-2013 Multiple Sclerosis Foundation - All Rights Reserved

�