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A new study casts doubt on MS indicators


The authors of a new study discovered that certain MS-associated autoreactive antibodies are not more frequent in MS patients compared to healthy individuals. Their results cast doubt on the reports that have suggested they can be used to determine that a patient has MS.

Researchers at Immco Diagnostics and the State University of New York in Buffalo investigated the role of autoantibodies against three putative MS antigens (CSF114(Glc), KIR 4.1a and KIR 4.1b peptides) and 26 other disease-linked antigens in 969 individuals. They found that the presence of autoreactive antibodies was not associated with clinical and MRI measures of MS disease progression.

They also failed to evidence that smoking was associated with increased levels of putative MS antibodies or with other disease-linked antibodies. The presence of autoantibodies was relatively infrequent in primary progressive MS compared to MS and healthy control groups.

The findings were published in the journal PLoS One.

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