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Study: Rogue proteins may be linked to MS

12/8/2014

In brain tissue and spinal fluid of multiple sclerosis patients, researchers identified a rogue protein that may be linked to the disease. The discovery may offer a link between MS and other neurodegenerative diseases.

Using antibodies designed to recognize rogue proteins in patients with Creutzfeldt-Jakob disease, scientists from the University of Surrey, University of Texas Medical Center and PrioCam Laboratories applied these antibodies to brain tissue and spinal fluid of MS patients. Researchers concluded that a protein that permanently adopts a rogue state may be the cause of MS.

“Our discovery proposes a new and alternative way to conduct research into multiple sclerosis, by, for the first time, identifying a clear link to other neurodegenerative diseases. The results are important in redefining the molecular and cellular make-up of these diseases, and provide an important milestone in the quest for a preclinical laboratory test and an effective cure," said Dr Mourad Tayebi, Senior Lecturer in Neuroimmunology from the School of Veterinary Medicine.

The study was published in the journal Frontiers in Neurology.



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